Updating the concept of prebiotics
Here is a brief history of what has happened and where to look for my latest thoughts: The birth of the blog Seven years ago, I thought that I could continue to update this treatise as I followed the key scientific streams related to health and aging.
Soon, I discovered that for older people, creating health and creating longevity amount to the same thing.
By about mid 2012 I was updating this treatise only selectively and somewhere in the middle of 2013 I gave up doing that completely except for listing blog entry links.
Other than for this FORWARD, I am now only listing new blog entries in the updates This treatise does not adequately cover a large number of important topics, mainly ones of newer science.
I will eventually rewrite this treatise from a different perspective.
Meanwhile, if you would like to understand how my thinking has evolved in the last five years, you can check out my May 2014 blog entry FIVE-YEAR PROGRESS REPORT ON MAJOR TRENDS IMPACTING ON LONGEVITY.
Some like lipofuscin accumulation, telomere shortening and tissue glycation and even cancers and heart diseases are definitely downstream in the causal chain.
I expect to be forwarding the development of that GUT in close cooperation with Jim Watson, and at some point this will become the subject of a new book.
As time progressed, the process of updating this treatise has became increasingly daunting, in part because its organization no longer reflects how I now think about longevity or longevity-related interventions.
Many of these are, however, covered fairly comprehensively in blog entries.
These include progress in stem cell research, many topics of epigenetics, several key gene-activation pathways, mitochondrial dynamics, redox related pathways, telomere-related pathways, health-producing properties of plant polyphenols, stress-responses and hormesis, quorum sensing in biofilms, microtubules, bacterial communications, nano delivery of therapeutic substances, quantum biology, systems biology, human bacterial biomes, roles of RNA species, age-related diseases including Alzheimers, Parkinsons, diabetes and cancers, evolutionary origins of our signaling systems, exosomal communication systems, cell senescence, signaling gasses, interspecies communications, circadian regulation and progress towards creating a Grand Unified Theory of biology and aging - to mention just a few.
For example, REDOX processes, central to the first theory of aging, actually play significant roles in each of the other theories.
Some of the theories are more basic and upstream of the others.
Search for updating the concept of prebiotics:
It seems that for everything I learn, I discover there are at least two new things yet to be learned.