Non sedating anti

An initial burst of mediator activity will often set a series of cell responses in motion which will amplify and prolong disturbances.

Once inflammation is established in tissues by immune cell invasion and mediator release, recovery may take several days to weeks.

These receptors both receive histamine as a messenger, but the meaning conveyed is different.

H1 receptors tend to produce the symptoms already listed and activate allergic reactions.

The common antihistamines (Benadryl, Chlortripalon, Atarax, Claritin, Seldane, and Hismanal) are H1 blockers.

The H1 block is useful to treat allergic reactions.

Histamine carries its message to a large number of cells by attaching to a special receptor on the cells' surfaces.

There are two kinds of histamine receptors, H1 and H2.

Almost everyone has taken an antihistamine to treat hay fever, itching, to relieve nausea and vomiting, in tablets and syrups used to treat cough and cold symptoms, or as an aid to sleep.Antihistamine sedative effects are increased by concurrent alcoholic beverage ingestion and by a long list of psychotropic drugs.The sedative effects of some foods such as milk and wheat in susceptible people is not blocked, but enhanced by antihistamines.The classic antihistamines are represented by chlorpheniramine ( Chlor-Tripalon), brompheniramine (Dimetane), diphenhydramine ( Benadryl) and dimenhydrinate (Gravol). These antihistamines have been marketed as allergy preparations for the relief of hay fever and hives and other itchy skin conditions.Antihistamines are included in over-the counter cold and cough preparations even though there is little evidence of benefit and unwanted side effects such as sedation can be risky.

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