Mechanism of action of sedating antihistamines
While having been shown to have some efficacy in preventing motion sickness, these are a controlled substance with a high abuse potential, and therefore should be prescribed with caution.This fact, along with its sedation properties, make it a poor choice.
Scopolamine, which is most commonly prescribed as a transdermal patch, should be administered at least 30 minutes prior to exposure to motion stimuli.
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[ Read the disclaimer | Adults: Allergic rhinitis, seasonal/perennial: 5 mg po qd. In patients with liver or renal impairment, a starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.
Some experts report the dose can be safely doubled by wearing either two patches or by supplementing the patch with oral scopolamine.
Mixture of 1:1 salt consisting of 8-chlorotheophylline and diphenhydramine.
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Scopolamine’s effectiveness is likely due to its central anticholinergic properties.